Current Mucoadhesive Drug Delivery System for Recurrent Aphthous Stomatitis
Published: 2022-05-12
Page: 124-140
Issue: 2022 - Volume 5 [Issue 1]
Parastoo Namdar
Iran Dental Research Center, Department of Orthodontics, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
Rezvan Yazdian-Robati
Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Pegah Mosannen Mozafari
Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Maryam Hashemi
Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Atena Shiva *
Iran Dental Research Center, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
*Author to whom correspondence should be addressed.
Abstract
Recurrent aphthous stomatitis (RAS) is the most common ulcerative disease of the oral mucosa, RAS is characterized by extremely painful, recurring solitary, multiple ulcers in the upper throat and oral cavity, which may lead to difficulty in eating, speaking and swallowing and negatively affects the life standard of the patient’s. In patients undergoing fixed orthodontic treatment, the frequency of RAU Increases .The underlying etiology of RAS is noted clear and no curative treatment is available. Current treatment for RAS is often in the form of mouthwashes, creams, or ointments, but these are often ineffective, due to inadequate drug contact times with the lesions and poorly available use of drug. To overcome these problems, it has been proposed to incorporate drugs to mucoadhesive polymers or nanoparticulate systems containing mucoadhesive polymer(s) because of their propensity to interact with the mucosal surface. Mucoadhesions increased the residence time of drug carriers at the site of absorption, improved drug absorption, and controlled drug release from the devices used. Smaller size of particles has been supposed to diffuse much higher in the mucus layer and improve the bioavailability of drugs. In the present review, we focus on the mocuadhesive drug delivery system in the treatment of RAS.
Keywords: Recurrent aphthous stomatitis, mucoadhesion, nanoparticles, oral mucosa