The Effectiveness of LLLT on Orthodontic Tooth Movement Acceleration: A Systematic Review of Human Studies
Asian Journal of Dental Sciences,
Background: Low level laser therapy (LLLT) has been verified efficacious in pain reduction. But the research results remain unclear and debatable in terms of orthodontic tooth movement (OTM) acceleration. Therefore, this systematic review was conducted to scrutinize the ability of photobiomodulation to increase the rate of orthodontic tooth movement.
Methods: A total of three databases were searched until July 2022. Controlled randomized clinical studies assessing the effect of photobiomodulation on the rate of orthodontic tooth movement published during the last 10 years in English were eligible to be selected. Study selection and data extraction were undertaken independently by two reviewers. Risk-of-bias (RoB) assessment was evaluated using Grade guidelines. The reporting of this review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
Results: A total of nine studies were identified for inclusion among 95 articles. A metanalysis could not be performed due to the heterogenity of the included studies. Six studies found a positive correlation between LLLT and acceleration of tooth movement. However, three trials found no significant difference between control and test group.
Conclusions: Based on the current moderate evidence, photobiomodulation could be an effective method on tooth movement acceleration. More well-designed randomized controlled trials are called for to obtain more clinically significant conclusions.
- tooth movement
How to Cite
Nabeel F. Talic. Adverse effects of orthodontic treatment : A clinical perspective. The Saudi Dental Journal. 2011;23:55–59.
Elif Keser, Farhad B. Naini. Accelerated orthodontic tooth movement : Surgical techniques and the regional acceleratory phenomenon. Maxillofacial Plastic and Reconstructive Surgery. 2022;44:1-21.
Fu T, Liu S, Zhao H, Cao M, Zhang R. Effectiveness and safety of minimally invasive orthodontic tooth movement acceleration : A systematic review and meta-analysis. Journal of Dental Research. 2019;(00) 0:1–11.
Lucas Garcia Santana, Lucas Duarte-Rodrigues, Ana Caroline Alves-Duarte, Endi Lanza Galvão, Dhelfeson Willya Douglas-de-Oliveira, Leandro Silva Marques, et al. Systematic review of biological therapy to accelerate orthodontic tooth movement in animals : Translational approach. Archives of Oral Biology. 2019;110:1-11.
Hoon Chung, Tianhong Dai, Sulbha K. Sharma, Ying-Ying Huang, James D Carroll, Michael R Hamblin. National Institutes of Health. 2012;40(2):516–533.
Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gøtzsche, John PA Ioannidis, et al. The PRiSMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions : explanation and elaboration. British Medical Journal. 2009;339.
Nick Meader, Kristel King, Alexis Llewellyn, Gill Norman, Jennifer Brown, Mark Rodgers, et al. A checklist designed to aid consistency and reproducibility of GRADE assessments : development and pilot validation. BioMed Central. 2014;3(82):1-9.
Safa Al-Shafi, Nikolaos Pandis, M. Ali Darendeliler, Alexandra K Papadopoulou. Effect of light-emitting diode–mediated photobiomodulation on extraction space closure in adolescents and young adults : A split-mouth, randomized controlled trial. American Journal of Orthodontics and Dentofacial Orthopedics. 2021;160:19-28.
Mohammad Moaffak A, AlSayed Hasana, Kinda Sultanb, Omar Hamadah. Low-level laser therapy effectiveness in accelerating orthodontic tooth movement : A randomized controlled clinical trial. Angle Orthodontist. 2017;87(4):499-405.
Farah Y Eid, Walid A El‑Kenany, Mohamed I Mowafy, Ahmed R El‑Kalza, Myriam A Guindi. A randomized controlled trial evaluating the effect of two low‑level laser irradiation protocols on the rate of canine retraction. Scientific Reports. 2022;12.
Abdullah Ekizer, Gokhan T urker, Tancan Uysal, Enis Guray, Zekeriya Tasdemir. Light emitting diode mediated photobiomodulation therapy improves orthodontic tooth movement and miniscrew stability : A randomized controlled clinical trial. Lasers in Surgery and Medicine; 2016.
Tharwat Osman El Shehawy, Farouk Ahmed Hussein, Akram Abbbas EI Awady. Outcome of photodynamic therapy on orthodontic leveling and alignment of mandibular anterior segment : A controlled clinical trial. Photodiagnosis and Photodynamic Therapy ; 2020.
Yasmine Khaled Abdel Ghaffara, Fouad A El Sharabyb, Ibrahim Mazen Negm. Effect of low-level laser therapy on the time needed for leveling and alignment of mandibular anterior crowding: A randomized controlled clinical trial. Angle Orthodontist. 2022;92(4):478-486.
Alessandra Impellizzeri, Martina Horodynski, Riccardo Fusco, Gaspare Palaia, Antonella Polimeni, Umberto Romeo, et al. Photobiomodulation therapy on orthodontic movement: Analysis of preliminary studies with a new protocol. International Journal of Environmental Research and Public Health. 2020;17:1-14.
Junyi Zheng, Kai Yang. Clinical research: Low-level laser therapy in accelerating orthodontic tooth movement. BMC Oral Health. 2021;21:1-7.
Alissa Maria Varella, Ameet V Revankar, Anand K Patil. Low-level laser therapy increases interleukin-1b in gingival crevicular fluid and enhances the rate of orthodontic tooth movement. American Journal of Orthodontics and Dentofacial Orthopedics. 2018;154 (4):535-544.
Yi J, Xiao J, Li H, Li Y, Li X, Zhao Z. Effectiveness of adjunctive interventions for accelerating orthodontic tooth movement: a systematic review of systematic reviews. Journal of Oral Rehabilitation. 2017;44:636–654.
Marineˆs Vieira da Silva Sousa, Marco Antonio Scanavini, Eduardo Kazuo Sannomiya, Leandro G. Velasco, Fernanda Angelieri. Influence of Low-level laser on the speed of orthodontic movement. Photomedicine and Laser Surgery. 2011;29(3):191–196.
Maciej Jedlin´ski, Umberto Romeo, Alessandro del Vecchio, Gaspare Palaia, Gabriela Galluccio. Comparison of the Effects of photobiomodulation with different lasers on orthodontic movement and reduction of the treatment time with fixed appliances in novel scientific reports : A systematic review with meta-analysis. Photobiomodulation, Photomedicine, and Laser Surgery; 2020.
Carlos Sechi Goulart, Paulo Roberto Aranha Nouer, Ivana Uglik Garbini, Rosane De Fatima Zanirato Lizarelli. Photoradiation and orthodontic movement: Experimental study with canines. Photomedicine and Laser Surgery. 2006; 24(2):192–196.
Abstract View: 58 times
PDF Download: 11 times