Periodontitis: A Hastened and Destructive Inflammatory Induced Senescence
Luay Thanoon Younis *
Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, 47000, Sungai Buloh, Malaysia.
Faisal Ismail Bahnasi
Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, 47000, Sungai Buloh, Malaysia.
Aida Nur Ashikin Abd Rahman
Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, 47000, Sungai Buloh, Malaysia.
Mohamed Ibrahim Abu Hassan
Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, 47000, Sungai Buloh, Malaysia.
*Author to whom correspondence should be addressed.
Abstract
Periodontitis is a chronic inflammation of tooth supporting tissues (periodontal ligament, alveolar bone and gingiva). Due to the chronic and intensive inflammation, these tissues undergo accelerated cellular senescence (premature cells cycle arrest). This accelerated cellular senescence ends up with their degeneration and dramatic changes in the normal aesthetic and architecture of the bone and gingiva of the affected individual. This review will provide insights into the detrimental and inevitable effect of inflammatory cellular senescence during periodontal disease progression.
Keywords: Periodontitis, inflammatory senescence, cell cycle arrest.