Main Article Content
Excessive exposure to fluoride during formation of teeth may lead to a severe hypomineralization condition, called dental fluorosis. Genes such as Collagen type 1 alpha 2 (COL1A2), Estrogen receptor (ESR), Prolactin (PRL), Catechol-o-methyltransferase (COMT), matrix metalloproteinase 20 (MMP20) and many others have been implicated in the incidence of dental fluorosis. This mini-review is an insight into the fact that fluorosis incidence and intensity are significantly related to individual’s genetic background.
Buzalaf MAR, Levy SM. Fluoride intake of children: considerations for dental caries and dental fluorosis. Monogr Oral Sci. 2011;22:1-19.
Wei W, Gao Y, Wang C, Zhao L, Sun D. Excessive fluoride induces endoplasmic reticulum stress and interferes enamel proteinases secretion. Environ Toxicol. 2013;28(6):332-41.
Den Besten P, Li W. Chronic fluoride toxicity: dental fluorosis. Monogr Oral Sci. 2011;22:81-96.
Bronckers AL, Lyaruu DM, DenBesten PK. The impact of fluoride on ameloblasts and the mechanisms of enamel fluorosis. Journal of Dental Research. 2009;88(10): 877-93.
Lyaruu DM, Medina JF, Sarvide S, Bervoets TJ, Everts V, Denbesten P, et al. Barrier formation: Potential molecular mechanism of enamel fluorosis. Journal of dental research. 2014;93(1):96-102.
DenBesten PK, Heffernan LM. Enamel proteases in secretory and maturation enamel of rats ingesting 0 and 100 PPM fluoride in drinking water. Adv Dent Res. 1989;3(2):199-202.
Den Besten PK. Effects of fluoride on protein secretion and removal during enamel development in the rat. Journal of Dental Research. 1986;65(10):1272-7.
Ramesh M, Narasimhan M, Krishnan R, Aruna RM, Kuruvilla S. The effect of fluorosis on human teeth under light microscopy: A cross-sectional study. J Oral Maxillofac Pathol. 2017;21(3):345-50.
Cury JA, Ricomini-Filho AP, Berti FLP, Tabchoury CP. Systemic effects (Risks) of water fluoridation. Brazilian Dental Journal. 2019;30:421-8.
DenBesten PK, Crenshaw MA. Studies on the changes in developing enamel caused by ingestion of high levels of fluoride in the rat. Adv Dent Res. 1987;1(2):176-80.
DenBesten PK, Crenshaw MA. The effects of chronic high fluoride levels on forming enamel in the rat. Archives of Oral Biology. 1984;29(9):675-9.
Denbesten PK, Crenshaw MA, Wilson MH. Changes in the fluoride-induced modulation of maturation stage ameloblasts of rats. Journal of denTal Research. 1985;64(12):1365-70.
DenBesten PK, Thariani H. Biological mechanisms of fluorosis and level and timing of systemic exposure to fluoride with respect to fluorosis. Journal of Dental Research. 1992;71(5):1238-43.
Robinson C, Connell S, Kirkham J, Brookes SJ, Shore RC, Smith AM. The effect of fluoride on the developing tooth. Caries Res. 2004;38(3):268-76.
Suzuki M, Shin M, Simmer JP, Bartlett JD. Fluoride affects enamel protein content via TGF-beta1-mediated KLK4 inhibition. Journal of Dental Research. 2014;93(10): 1022-7.
Tye CE, Antone JV, Bartlett JD. Fluoride does not inhibit enamel protease activity. Journal of Dental Research. 2011;90(4): 489-94.
Gerlach RF, de Souza AP, Cury JA, Line SR. Fluoride effect on the activity of enamel matrix proteinases in vitro. European Journal of Oral Sciences. 2000; 108(1):48-53.
Guo J, Lyaruu DM, Takano Y, Gibson CW, DenBesten PK, Bronckers AL. Amelogenins as potential buffers during secretory-stage amelogenesis. Journal of dental Research. 2015;94(3): 412-20.
Bronckers AL. Ion transport by ameloblasts during amelogenesis. Journal of dental Research. 2017;96(3):243-53.
Ji M, Xiao L, Xu L, Huang S, Zhang D. How pH is regulated during amelogenesis in dental fluorosis. Exp Ther Med. 2018; 16(5):3759-65.
Abou Neel EA, Aljabo A, Strange A, Ibrahim S, Coathup M, Young AM, et al. Demineralization-remineralization dynamics in teeth and bone. Int J Nanomedicine. 2016;11:4743-63.
Simmer JP, Fincham AG. Molecular mechanisms of dental enamel formation. Critical reviews in oral biology and medicine: An official publication of the American Association of Oral Biologists. 1995;6(2):84-108.
Palmer LC, Newcomb CJ, Kaltz SR, Spoerke ED, Stupp SI. Biomimetic systems for hydroxyapatite mineralization inspired by bone and enamel. Chem Rev. 2008;108(11):4754-83.
Onuma K, Iijima M. Artificial enamel induced by phase transformation of amorphous nanoparticles. Sci Rep. 2017; 7(1):2711.
Chachra D, Vieira AP, Grynpas MD. Fluoride and mineralized tissues. Crit Rev Biomed Eng. 2008;36(2-3):183-223.
Rango T, Vengosh A, Jeuland M, Whitford GM, Tekle-Haimanot R. Biomarkers of chronic fluoride exposure in groundwater in a highly exposed population. Sci Total Environ. 2017;596-597:1-11.
Mousny M, Banse X, Wise L, Everett ET, Hancock R, Vieth R, et al. The genetic influence on bone susceptibility to fluoride. Bone. 2006;39(6):1283-9.
Vieira AP, Hanocock R, Eggertsson H, Everett ET, Grynpas MD. Tooth quality in dental fluorosis genetic and environmental factors. Calcif Tissue Int. 2005;76(1):17-25.
Bhagavatula P, Levy SM, Broffitt B, Weber-Gasparoni K, Warren JJ. Timing of fluoride intake and dental fluorosis on late-erupting permanent teeth. Community Dent Oral Epidemiol. 2016;44(1):32-45.
Hong L, Levy SM, Broffitt B, Warren JJ, Kanellis MJ, Wefel JS, et al. Timing of fluoride intake in relation to development of fluorosis on maxillary central incisors. Community Dent Oral Epidemiol. 2006;34 (4):299-309.
Everett ET. Fluoride's effects on the formation of teeth and bones and the influence of genetics. Journal of Dental Research. 2011;90(5):552-60.
Everett ET, McHenry MA, Reynolds N, Eggertsson H, Sullivan J, Kantmann C, et al. Dental fluorosis: Variability among different inbred mouse strains. Journal of Dental Research. 2002;81(11): 794-8.
Everett ET, Yan D, Weaver M, Liu L, Foroud T, Martinez-Mier EA. Detection of dental fluorosis-associated quantitative trait Loci on mouse chromosomes 2 and 11. Cells Tissues Organs. 2009;189(1-4):212-8.
Everett ET, Yin Z, Yan D, Zou F. Fine mapping of dental fluorosis quantitative trait loci in mice. European Journal of Oral Sciences. 2011;119(Suppl 1):8-12.
Huang H, Ba Y, Cui L, Cheng X, Zhu J, Zhang Y, et al. COL1A2 gene polymorphisms (Pvu II and Rsa I), serum calciotropic hormone levels, and dental fluorosis. Community Dent Oral Epidemiol. 2008;36(6):517-22.
Kuchler EC, Dea Bruzamolin C, Ayumi Omori M, Costa MC, Antunes LS, Pecharki GD, et al. Polymorphisms in nonamelogenin enamel matrix genes are associated with dental fluorosis. Caries Res. 2018;52(1-2):1-6.
Ko L, Thiessen KM. A critique of recent economic evaluations of community water fluoridation. Int J Occup Environ Health. 2015;21(2):91-120.
Aguilar-Diaz FC, Irigoyen-Camacho ME, Borges-Yanez SA. Evaluation of a fluorosis prevention educational program: A randomized field trial. J Clin Exp Dent. 2018;10(5):e469-e76.
Martinez-Mier EA, Soto-Rojas AE. Differences in exposure and biological markers of fluoride among White and African American children. J Public Health Dent. 2010;70(3):234-40.
Carvalho JG, Leite AL, Yan D, Everett ET, Whitford GM, Buzalaf MA. Influence of genetic background on fluoride metabolism in mice. Journal of Dental Research. 2009; 88(11):1054-8.
Pramanik S, Saha D. The genetic influence in fluorosis. Environ Toxicol Pharmacol. 2017;56:157-62.
Charone S, Kuchler EC, Leite AL, Silva Fernandes M, Taioqui Pela V, Martini T, et al. Analysis of polymorphisms in genes differentially expressed in the enamel of mice with different genetic susceptibilities to dental fluorosis. Caries Res. 2019;53(2): 228-33.
Jarquin-Yneza L, Alegria-Torres JA, Castillo CG, de Jesus Mejia-Saavedra J. Dental fluorosis and a polymorphism in the COL1A2 gene in Mexican children. Archives of Oral Biology. 2018;96:21-5.
Dalledone M, Cunha AS, Ramazzotto LA, Pecharki GD, Nelson-Filho P, Scariot R, et al. Estrogen receptor gene is associated with dental fluorosis in Brazilian children. Clin Oral Investig. 2019;23(9):3565-70.
Romualdo PC, Pucinelli CM, Tannure PN, Nelson-Filho P, Segato RAB, Brancher JA, et al. Evaluation of genetic polymorphisms in MMP2, MMP9 and MMP20 in Brazilian children with dental fluorosis. Environ Toxicol Pharmacol. 2019;66:104-8.
Wei W, Pang S, Sun D. The pathogenesis of endemic fluorosis: Research progress in the last 5 years. J Cell Mol Med. 2019;23 (4):2333-42.
Wu J, Wang W, Liu Y, Sun J, Ye Y, Li B, et al. Modifying role of GSTP1 polymorphism on the Association between tea fluoride exposure and the brick-tea type fluorosis. PLoS One. 2015;10(6):e0128280.
Rahila C, Aswath Narayanan MB, Ramesh Kumar SG, Leena Selvamary A, Sujatha A, John Kirubaharan J. Association of COL1A2 (PvuII) gene polymorphism with risk and severity of dental fluorosis - A case control study. Saudi Dent J. 2019;31 (4):463-8.
Zhang T, Shan KR, Tu X, He Y, Pei JJ, Guan ZZ. Myeloperoxidase activity and its corresponding mRNA expression as well as gene polymorphism in the population living in the coal-burning endemic fluorosis area in Guizhou of China. Biol Trace Elem Res. 2013;152(3):379-86.
Zhang YL, Luo Q, Deng Q, Li T, Li Y, Zhang ZL, et al. Genes associated with sodium fluoride-induced human osteoblast apoptosis. Int J Clin Exp Med. 2015;8(8): 0013171-8.
Kuchler EC, Tannure PN, Oliveira DS, Charone S, Nelson-Filho P, Silva RA, et al. Polymorphisms in genes involved in enamel development are associated with dental fluorosis. Archives of Oral Biology. 2017;76:66-9.
Arora S, Kumar JV, Moss ME. Does water fluoridation affect the prevalence of enamel fluorosis differently among racial and ethnic groups? J Public Health Dent. 2018;78(2):95-9.
Kubota K, Lee DH, Tsuchiya M, Young CS, Everett ET, Martinez-Mier EA, et al. Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation. J Biol Chem. 2005;280(24): 23194-202.
Zhang Y, Zhang K, Ma L, Gu H, Li J, Lei S. Fluoride induced endoplasmic reticulum stress and calcium overload in ameloblasts. Archives of Oral Biology. 2016;69:95-101.
Pluquet O, Pourtier A, Abbadie C. The unfolded protein response and cellular senescence. A review in the theme: Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. Am J Physiol Cell Physiol. 2015;308(6):C415-25.
Sano R, Reed JC. ER stress-induced cell death mechanisms. Biochim Biophys Acta. 2013;1833(12):3460-70.