Dental Fluorosis: Dilemma of Genetic Susceptibility

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Luay Thanoon Younis
Faatin Afeefah Ahmad Naqiyuddin
Afiqah Azhar
Ahmad Izzat Arief Amron
Aida Nur Ashikin Abd Rahman
Mohamed Ibrahim Abu Hassan


Excessive exposure to fluoride during formation of teeth may lead to a severe hypomineralization condition, called dental fluorosis. Genes such as Collagen type 1 alpha 2 (COL1A2), Estrogen receptor (ESR), Prolactin (PRL), Catechol-o-methyltransferase (COMT), matrix metalloproteinase 20 (MMP20) and many others have been implicated in the incidence of dental fluorosis. This mini-review is an insight into the fact that fluorosis incidence and intensity are significantly related to individual’s genetic background.

Fluorosis, fluoride, COL1A2, gene.

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How to Cite
Younis, L. T., Naqiyuddin, F. A. A., Azhar, A., Amron, A. I. A., Rahman, A. N. A. A., & Hassan, M. I. A. (2020). Dental Fluorosis: Dilemma of Genetic Susceptibility. Asian Journal of Dental Sciences, 3(1), 21-26. Retrieved from
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