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Neurofibroma is a rare benign Non-odontogenic tumor which may occur predominantly as a feature of Von Recklinghausen’s disease affecting the soft tissue. Intraorally, the intraosseous solitary variant of neurofibroma is a very rare entity thereby intriguing the oral physicians. We report a rare case of solitary intraosseous neurofibroma involving the mandibular foramen on the right side of the mandible without a family history of Von Recklinghausen’s disease in a 39 year aged female patient. The diagnosis was made based on clinical and radiological findings and histopathological report. On serological investigation the patient was HIV positive. The present case is rare in regard to its location and the immunodeficiency condition of the patient.